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Relationship Between Cervical Cancer And HPV

Relationship Between Cervical Cancer And HPV

About 10% of Omanis women with HPV on their cervix will develop long-term HPV infections, putting them at risk for cervical cancer. Similarly, when high-risk HPV lingers and infects the vulva, vaginal, penis, or anus cells, it can cause cell changes known as precancers.


Cervical vs HPV

The Human Papillomavirus (HPV) is a family of more than 100 closely related viruses that attack various body organs. About 40 of them can cause genital infections. The major way that HPV is spread is through skin-to-skin sex. Additionally, HPV can spread through oral sex and genital-to-genital contact without penetration. At least 12 different forms of HPV, also known as oncogenic/high-risk strains, are known to cause cervical cancer. Although considerably less common than cervical cancer, these high-risk strains can also cause malignancies of the oropharynx, vagina, vulva, penis, and anus. The remaining HPV strains may result in genital warts.

The fourth most frequent malignancy in women worldwide and the tenth most prevalent among Singaporean women is cervical cancer.


False Impression

HPV is primarily a female-specific disease. Many people think that women who engage in regular intercourse are more likely to contract HPV. The likelihood of exposure can rise with the number of sexual partners. But in reality, any woman who has ever engaged in sexual activity—even with a single partner—is at risk of having been exposed to HPV. By the age of 50, it is anticipated that 80% of women will have experienced HPV at some point.

You will develop cervical cancer if you have HPV

The presence of HPV does not guarantee cervical cancer or its development. Usually, the immune system clears the infection on its own. The majority of people are not even aware that they have HPV.

About 10% of infections might linger for a longer time, giving rise to aberrant cells that eventually turn into cervical cancer. The goal of the cervical cancer screening program is to identify these women for closer observation and care. Before cervical cancer has an opportunity to develop, precancerous cell alterations brought on by the HPV virus can be identified and treated.


HPV Test For Cervical Cancer

You no longer require Pap or HPV testing if you receive the HPV vaccination. Only nine out of the twelve cancer-causing HPV strains are protected against by the HPV vaccine. Even then, the vaccine’s effectiveness depends on whether it is administered to women who have not yet been exposed to HPV. When given to women older than 27 and those who have had sexual activity, the vaccine’s effectiveness decreases.

An adolescent girl or young woman between the ages of 9 and 27 who have never engaged in sexual activity is the best candidate for the vaccine. Regardless of their level of immunization, all sexually active women should get routine Pap and/or HPV testing.


Abnormal Pap

Cervical cancer is detected via an abnormal Pap test. Precancerous alterations rather than cervical cancer are typically detected by an abnormal Pap test. Other causes besides the existence of precancerous cells may be responsible for the anomaly.

There are many grades of abnormalities that are found when a Pap test is considered “abnormal.” Your doctor will use this rating to determine whether pre-cancer is a possibility. Atypical cells of unclear importance, which can be brought on by dryness, a local irritant, a non-HPV infection, or a low-risk HPV type, will be the most typical grade. A gynecologist must evaluate a PAP test that is abnormal to identify the appropriate course of action.


Result Of Research In OMAN

It’s critical to discover elements that have the strongest etiopathogenetic associations with the cervical cancer-causing process in addition to early detection of changes to avoid cervical cancer. A high-oncology risk group can be found and then given tighter control by identifying and classifying those who have an HPV infection. The population investigated and the method employed to detect the virus has an impact on the findings of attempts to determine the prevalence of HPV infection among women with subclinical or latent disease. The Papilloma family of human viruses does not reproduce in cell cultures, and no animal infection and virus breeding model has been created to date.

Standard serological techniques cannot be applied in vitro cultures due to the challenge of obtaining a viral antigen. Only with the invention of molecular biology techniques was it possible to detect HPV infection. The highest sensitivity of all currently available molecular biology methods, the PCR reaction, is used to diagnose the majority of illnesses. You can use it to show that 105–106 cells contain one copy of the HPV virus. PCR is now a widely utilized diagnostic method in numerous laboratories. The results acquired on this basis can be compared and, to a certain extent, their incorrect interpretation can be avoided.


Factors That Affect HPV Vaccination

Cervical cancer is the third most prevalent malignancy in people between the ages of 15 and 44 in Oman, according to figures from the Opal BioPharma firm.

Determinants affecting HPV vaccine uptake have received a lot of research. The majority of research has discovered that the perceived advantages of the vaccine have a significant impact on decisions regarding vaccination; the intention to vaccinate rises with the perceived advantages. The perceived effectiveness of the vaccine, beliefs that it will prevent or lessen the severity of HPV-related disease, and/or beliefs that it will promote the future health of recipients, their future partners, and other members of the community through herd immunity are among the most frequently reported benefits.

Deciding whether or not to receive an HPV vaccination is also influenced by perceived obstacles. The low perceived efficiency of the vaccine, worries about side effects and safety, a fear of needles, and a fear of the stigma associated with sexual promiscuity or sexual disinhibition are among the reported hurdles. The latter include false beliefs about the actual injection location and the vaccine’s preventive impact.

Additionally, because the HPV vaccine has mostly been promoted for women, few men are aware that it is available. As a result, men have not become routine recipients of the HPV vaccine, potentially degrading those who choose to receive it. Other obstacles, such as a lack of faith in the government and/or worries about pharmaceutical corporations’ financial interests, have also been claimed to interfere.


Prevention Is Better Than Cure

Opal BioPharma‘s study indicates that treatments cannot completely rid your body of the infection. Another theme that emerged from this point of view was the perceived complexity of HPV and HPV-related diseases, which was reflected in beliefs about who should make the vaccination decision, whether it be children alone or parents and children together. Parents stated that they would rather tell their children about their decision than negotiate it with them. They were convinced that children who received formal invitation letters for local vaccination sessions were incapable of comprehending such complex information and making informed decisions.


Fear Of Unanticipated Side Effects

This viewpoint was dominated by perceived barriers, specifically fear of the unknown long-term side effects of HPV vaccination. In this way, HPV vaccination differed from other childhood immunizations. “[I have] concerns about the long-term side effects,” one mother said. The vaccine was only recently developed. The potential long-term side effects are unknown.” Respondents also discussed vaccine efficacy, emphasizing that the current vaccine does not protect against all cancer-causing HPV strains. One interviewee also questioned the vaccine’s duration of protection against HPV infection.


Factors Influencing HPV Vaccination

The factors affecting the uptake of the HPV vaccine have received a lot of attention. The majority of research has discovered that the perceived vaccine advantages have a significant impact on individuals’ decisions about whether or not to get vaccinated; the intention to get vaccinated rises with the perceived benefits. Vaccine efficacy is frequently cited as a benefit, along with the notion that it will prevent or lessen the severity of HPV-related disease and/or improve future health through herd immunity for recipients, their future relationships, and other members of the community.

Additionally, because the HPV vaccine has mostly been promoted for women, few men are aware that it is available. As a result, men have not become routine recipients of the HPV vaccine, potentially degrading those who choose to receive it. Uptake of the HPV vaccine has also been claimed to be hampered by other obstacles, such as low faith in the government (which is marketing the vaccine) and/or worries about the financial interests of pharmaceutical corporations.



Omanis research found four common attitudes toward HPV vaccination among girls, boys, and parents. Given the goal of publicly funded vaccination programs to reduce the spread of HPV infection and HPV-related disease, as well as concerns about current uptake, policies wishing to promote uptake must be aware of existing public perspectives on HPV vaccination. The HPV vaccine differs from other childhood vaccinations in NIPs, as vaccinating against HPV is not always considered “the natural thing to do.” Increasing awareness and knowledge by investing in tailored communication policies could aid in vaccine uptake among those who are unfamiliar with the vaccine.

This is especially true for those who held perspectives 3 or 4, as they appeared to be in a modifiable phase. Despite the study’s non-generalizability, the methods and findings could aid in the development of campaigns aimed at increasing HPV vaccination uptake.

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